Hyperglycemia as an effect of cardiopulmonary bypass: Intra-operative glucose management

Samira Najmaii, Daniel Redford, Douglas F. Larson

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Cardiopulmonary bypass (CPB) is associated with surgical stress, hypothermia, hyperoxia, enhancement of neuroendocrine outflow, and administration of glucogenic catecholamines that are associated with glucogonolysis and glucogenesis that result in hyperglycemia. The hyperglycemic state during CPB has been associated with adverse outcomes, such as infection, neurological impairment, cardiac dysfunction, prolonged hospitalization, and higher mortality rates. This report justifies vigilant monitoring of blood glucose levels and a rational protocol for the treatment of hyperglycemia of all open heart surgical patients that may improve post-CPB surgical outcomes.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalJournal of Extra-Corporeal Technology
Issue number2
StatePublished - Jun 2006


  • GLUT2
  • GLUT4
  • Glucose
  • Glycogen
  • Hyperglycemia
  • Hyperoxia
  • Hypothermia
  • Insulin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Cardiology and Cardiovascular Medicine


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