Hypercoagulability in the perioperative period

Vance G. Nielsen, Lars M. Asmis

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


One of the greatest disappointments associated with a successful surgical procedure is a thrombotic or thrombo-embolic complication in the postoperative period. Morbidity and mortality of the perioperative period are related, to a relevant degree, to perioperative thrombo-embolic events. Ranging from simple deep venous thrombosis to pulmonary embolism or arterial thrombosis, this class of complication invariably increases length of hospital stay or may result in mortality. The purpose of this review is to identify the procedures and patient populations noted to have thrombophilia in the postoperative period, link the changes in circulating and in situ haematological/biochemical substrates most likely responsible for morbidity, identify the clinical diagnostic modalities that detect recent/impending thrombosis and, lastly, consider the rational therapeutic approaches recommended for minimising postoperative thrombotic complications.

Original languageEnglish (US)
Pages (from-to)133-144
Number of pages12
JournalBest Practice and Research: Clinical Anaesthesiology
Issue number1
StatePublished - Mar 2010


  • fibrinolysis
  • haemostatic monitoring
  • low-molecular-weight heparins
  • perioperative hypercoagulability
  • thrombelastography
  • thrombophilia
  • thromboprophylaxis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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