TY - JOUR
T1 - Hydrolysis of nitrite esters
T2 - Putative intermediates in the biotransformation of organic nitrates
AU - Buckell, Felicity
AU - Hartry, Jeffrey D.
AU - Rajalingam, Umarani
AU - Bennett, Brian M.
AU - Whitney, Ralph A.
AU - Thatcher, Gregory R.J.
PY - 1994
Y1 - 1994
N2 - Study and comparison of the pH-independent hydrolysis of eight alkyl nitrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediate in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermediate in aqueous solution, suggesting a role for neighbouring group participation by the β-nitrate group.
AB - Study and comparison of the pH-independent hydrolysis of eight alkyl nitrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediate in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermediate in aqueous solution, suggesting a role for neighbouring group participation by the β-nitrate group.
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U2 - 10.1039/p29940000401
DO - 10.1039/p29940000401
M3 - Article
AN - SCOPUS:37049076918
SN - 1472-779X
SP - 401
EP - 403
JO - Journal of the Chemical Society, Perkin Transactions 2
JF - Journal of the Chemical Society, Perkin Transactions 2
IS - 3
ER -