Study and comparison of the pH-independent hydrolysis of eight alkyl nitrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediate in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermediate in aqueous solution, suggesting a role for neighbouring group participation by the β-nitrate group.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the Chemical Society, Perkin Transactions 2|
|State||Published - 1994|
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