Hybrid nanoparticles for combination therapy of cancer

Chunbai He, Jianqin Lu, Wenbin Lin

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Nanoparticle anticancer drug delivery enhances therapeutic efficacies and reduces side effects by improving pharmacokinetics and biodistributions of the drug payloads in animal models. Despite promising preclinical efficacy results, monotherapy nanomedicines have failed to produce enhanced response rates over conventional chemotherapy in human clinical trials. The discrepancy between preclinical data and clinical outcomes is believed to result from the less pronounced enhanced permeability and retention (EPR) effect in and the heterogeneity of human tumors as well as the intrinsic/acquired drug resistance to monotherapy over the treatment course. To address these issues, recent efforts have been devoted to developing nanocarriers that can efficiently deliver multiple therapeutics with controlled release properties and increased tumor deposition. In ideal scenarios, the drug or therapeutic modality combinations have different mechanisms of action to afford synergistic effects. In this review, we summarize recent progress in designing hybrid nanoparticles for the co-delivery of combination therapies, including multiple chemotherapeutics, chemotherapeutics and biologics, chemotherapeutics and photodynamic therapy, and chemotherapeutics and radiotherapy. The in vitro and in vivo anticancer effects are also discussed.

Original languageEnglish (US)
Pages (from-to)224-236
Number of pages13
JournalJournal of Controlled Release
Volume219
DOIs
StatePublished - Dec 10 2015
Externally publishedYes

Keywords

  • Co-delivery
  • Combination therapy of cancer
  • Hybrid nanoparticle
  • Synergistic effect

ASJC Scopus subject areas

  • Pharmaceutical Science

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