@inbook{a23be295229e4f5cb19f04d9803c44ca,
title = "Human telomeric G-quadruplex structures and G-quadruplex-interactive compounds",
abstract = "G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3′ G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR and biophysical methodology used in our research group for the study of G-quadruplex structures in physiologically relevant solution and their interactions with small-molecule compounds.",
keywords = "Anticancer drug targets, G-Quadruplex structures, G-Quadruplex-interactive compounds, Human telomeres, Structure polymorphism, Telomerase inhibitors",
author = "Clement Lin and Danzhou Yang",
note = "Funding Information: This research was supported by the National Institutes of Health funding (1S10RR16659, CA122952, GM083117, and CA177585). We thank Dr. Megan Carver for proofreading the manuscript. Publisher Copyright: {\textcopyright} Springer Science+Business Media LLC 2017.",
year = "2017",
doi = "10.1007/978-1-4939-6892-3_17",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "171--196",
booktitle = "Methods in Molecular Biology",
}