Human Internal Mammary Artery (IMA) transplantation and stenting: A human model to study the development of In-Stent Restenosis

Xiaoqin Hua; Tobias Deuse; Evangelos D. Michelakis; Alois Haromy; Phil S. Tsao; Lars Maegdefessel; Reinhold G. Erben; Claudia Bergow; Boris B. Behnisch; Hermann Reichenspurner; Robert C. Robbins; Sonja Schrepfer

doi:10.3791/3663

Human Internal Mammary Artery (IMA) transplantation and stenting: A human model to study the development of In-Stent Restenosis

Xiaoqin Hua, Tobias Deuse, Evangelos D. Michelakis, Alois Haromy, Phil S. Tsao, Lars Maegdefessel, Reinhold G. Erben, Claudia Bergow, Boris B. Behnisch, Hermann Reichenspurner, Robert C. Robbins, Sonja Schrepfer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches^1,2. The commonly used animal models include mice, rats, rabbits, and pigs^3-5. However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models^6,7. In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.

Original language	English (US)
Article number	e3663
Journal	Journal of Visualized Experiments
Issue number	63
DOIs	https://doi.org/10.3791/3663
State	Published - May 9 2012
Externally published	Yes

Keywords

Biomedical engineering
Human internal mammary artery (IMA) transplantation
Issue 63
Physiology
Restenosis
Stent

ASJC Scopus subject areas

General Neuroscience
General Chemical Engineering
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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Hua, X., Deuse, T., Michelakis, E. D., Haromy, A., Tsao, P. S., Maegdefessel, L., Erben, R. G., Bergow, C., Behnisch, B. B., Reichenspurner, H., Robbins, R. C., & Schrepfer, S. (2012). Human Internal Mammary Artery (IMA) transplantation and stenting: A human model to study the development of In-Stent Restenosis. Journal of Visualized Experiments, (63), Article e3663. https://doi.org/10.3791/3663

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title = "Human Internal Mammary Artery (IMA) transplantation and stenting: A human model to study the development of In-Stent Restenosis",

abstract = "Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches1,2. The commonly used animal models include mice, rats, rabbits, and pigs3-5. However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models6,7. In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.",

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author = "Xiaoqin Hua and Tobias Deuse and Michelakis, {Evangelos D.} and Alois Haromy and Tsao, {Phil S.} and Lars Maegdefessel and Erben, {Reinhold G.} and Claudia Bergow and Behnisch, {Boris B.} and Hermann Reichenspurner and Robbins, {Robert C.} and Sonja Schrepfer",

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AU - Haromy, Alois

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AU - Maegdefessel, Lars

AU - Erben, Reinhold G.

AU - Bergow, Claudia

AU - Behnisch, Boris B.

AU - Reichenspurner, Hermann

AU - Robbins, Robert C.

AU - Schrepfer, Sonja

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AB - Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches1,2. The commonly used animal models include mice, rats, rabbits, and pigs3-5. However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models6,7. In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.

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Human Internal Mammary Artery (IMA) transplantation and stenting: A human model to study the development of In-Stent Restenosis

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