Human hippocampal CA1 involvement during allocentric encoding of spatial information

Nanthia A. Suthana, Arne D. Ekstrom, Saba Moshirvaziri, Barbara Knowlton, Susan Y. Bookheimer

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

A central component of our ability to navigate an environment is the formation of a memory representation that is allocentric and thus independent of our starting point within that environment. Computational models and rodent electrophysiological recordings suggest a critical role for the CA1 subregion of the hippocampus in this type of coding; however, the hippocampal neural basis of spatial learning in humans remains unclear. We studied subjects learning virtual environments using high-resolution functional magnetic resonance imaging (1.6 mm x 1.6 mm in-plane) and computational unfolding to better visualize substructural changes in neural activity in the hippocampus. We show that the right posterior CA1 subregion is active and positively correlated with performance when subjects learn a spatial environment independent of starting point and direction. Altogether, our results demonstrate that theCA1subregion is involved in our ability to learn a map-like representation of an environment.

Original languageEnglish (US)
Pages (from-to)10512-10519
Number of pages8
JournalJournal of Neuroscience
Volume29
Issue number34
DOIs
StatePublished - Aug 26 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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