Human Gastrointestinal Organoid Models for Studying Microbial Disease and Cancer

Jayati Chakrabarti, Martha B. Dua-Awereh, Loryn Holokai, Yana Zavros

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the major discoveries in stem cell research in the past decade embraces the development of “organs in a dish,” also known as “organoids.” Organoids are three-dimensional cellular structures derived from primary stem cells of different organ-specific cell types which are capable of self-renewal and maintenance of the parental lineages. Researchers have developed in vitro organoid models to mimic in vivo host–microbial interactions and disease. In this review, we focus on the use of gastrointestinal organoids as models of microbial disease and cancer.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Science and Business Media Deutschland GmbH
Pages55-75
Number of pages21
DOIs
StatePublished - 2021

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume430
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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