@inbook{d8ead4a61b9c4b65bc0abe6b469ba863,
title = "Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment",
abstract = "The study of cognitive function in Down syndrome (DS) has advanced rapidly in the past decade. Mouse models have generated data regarding the neurological basis for the specific cognitive profile of DS (i.e., deficits in aspects of hippocampal, prefrontal, and cerebellar function) and have uncovered pharmacological treatments with the potential to affect this phenotype. Given this progress, the field is at a juncture in which we require assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this chapter, we describe the cognitive profile of humans with DS and associated mouse models, discussing the ways in which we may merge these findings so as to more fully understand cognitive strengths and weaknesses in this population. New directions for approaches to cognitive assessment in mice and humans are discussed.",
keywords = "Cerebellum, Cognitive assessment, Down syndrome, Medial temporal lobe function, Mouse models, Mouse phenotype, Pharmacological intervention, Prefrontal function",
author = "Edgin, \{Jamie O.\} and Mason, \{Gina M.\} and Goffredina Span{\`o} and Andrea Fern{\'a}ndez and Lynn Nadel",
note = "Funding Information: We thank the families who made this work possible. Our work is supported in part by grants from the Down Syndrome Research and Treatment Foundation, DSRTF (to L. N. and J. O. E.); the Thrasher Research Fund (to L. N. and J. O. E.); the Lejeune Foundation (to J. O. E.); and the University of Arizona Foundation (to L. N.). We are also grateful to Bruce Pennington for allowing us to reanalyze some data from our past projects conducted with him.",
year = "2012",
doi = "10.1016/B978-0-444-54299-1.00007-8",
language = "English (US)",
series = "Progress in Brain Research",
publisher = "Elsevier B.V.",
pages = "123--151",
booktitle = "Progress in Brain Research",
}