We have determined that fractal analysis of the alveolar perimeter (D(f)) changes with aging in human lung tissue in twenty-nine patients, age range of 25 hours to 76 years, who died of non-respiratory related causes. There was a very significant difference (p = 0.0004) in D(f) between the young (less than 16 years old, N=9, mean D(f) of 1.047 [0.01]) and adult (greater than 16 years old, N=20, mean D(f) of 1.093 [0.013]) groups. Furthermore, there was a significant difference in D(f) between the Adult group and the group of patients who died of chronic obstructive pulmonary disease (COPD, N=10) (p = 0.012). Additionally, the D(f) values for the COPD and cystic fibrosis (CF, N = 5) groups were virtually identical; 1.061 and 1.070, respectively. Regression analysis showed a significant (p = 0.0041) exponential relationship with a correlation coefficient of 0.59 between aging and D(f). We have demonstrated that the correlation between D(f) and aging in humans is an exponential function and that the end-stage pulmonary diseases of COPD and CF decrease D(f).
|Original language||English (US)|
|Number of pages||10|
|Journal||Research Communications in Molecular Pathology and Pharmacology|
|State||Published - 1997|
ASJC Scopus subject areas
- Molecular Medicine