Hsp90 depletion goes wild

Mark L. Siegal; Joanna Masel

doi:10.1186/1741-7007-10-14

Hsp90 depletion goes wild

Mark L. Siegal, Joanna Masel

Ecology and Evolutionary Biology

Research output: Contribution to journal › Comment/debate › peer-review

16 Scopus citations

Abstract

Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25.

Original language	English (US)
Article number	14
Journal	BMC biology
Volume	10
DOIs	https://doi.org/10.1186/1741-7007-10-14
State	Published - Feb 27 2012

ASJC Scopus subject areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Plant Science
Developmental Biology
Cell Biology

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Hsp90 depletion goes wild

Abstract

ASJC Scopus subject areas

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