TY - JOUR
T1 - How recent learning shapes the brain
T2 - Memory-dependent functional reconfiguration of brain circuits
AU - Passiatore, Roberta
AU - Antonucci, Linda A.
AU - Bierstedt, Sabine
AU - Saranathan, Manojkumar
AU - Bertolino, Alessandro
AU - Suchan, Boris
AU - Pergola, Giulio
N1 - Funding Information:
Giulio Pergola has received a travel award for an academic exchange program from the non-profit organization Boehringer Ingelheim Fonds leading to this work. Boris Suchan was funded by a grant covering scan acquisition costs (Sonderforschungsbereich 874, CRC 874) from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, Project B8). We thank Philips Germany, especially Burkhard Maedler for continuous scientific support. Roberta Passiatore's scholarship was funded by a Collaboration Grant from Exprivia SpA, awarded to Alessandro Bertolino. Linda A. Antonucci's position was funded by the Structural European Funding of the Italian Minister of Education (Attraction and International Mobility—AIM—action, Grant No. 1859959). We would also like to thank Rita Cosoli, Grazia Difonzo, Dr. Leonardo Fazio, Valentina Felici, Christine Huecke, Dr. Robert Lech, Dr. Alfonso Monaco, Monica Nicoli, and Nora Penzel for their help at different stages of this research.
Publisher Copyright:
© 2021
PY - 2021/12/15
Y1 - 2021/12/15
N2 - The process of storing recently encoded episodic mnestic traces so that they are available for subsequent retrieval is accompanied by specific brain functional connectivity (FC) changes. In this fMRI study, we examined the early processing of memories in twenty-eight healthy participants performing an episodic memory task interposed between two resting state sessions. Memory performance was assessed through a forced-choice recognition test after the scanning sessions. We investigated resting state system configuration changes via Independent Component Analysis by cross-modeling baseline resting state spatial maps onto the post-encoding resting state, and post-encoding resting state spatial maps onto baseline. We identified both persistent and plastic components of the overall brain functional configuration between baseline and post-encoding. While FC patterns within executive, default mode, and cerebellar circuits persisted from baseline to post-encoding, FC within the visual circuit changed. A significant session × performance interaction characterized medial temporal lobe and prefrontal cortex FC with the visual circuit, as well as thalamic FC within the executive control system. Findings reveal early-stage FC changes at the system-level subsequent to a learning experience and associated with inter-individual variation in memory performance.
AB - The process of storing recently encoded episodic mnestic traces so that they are available for subsequent retrieval is accompanied by specific brain functional connectivity (FC) changes. In this fMRI study, we examined the early processing of memories in twenty-eight healthy participants performing an episodic memory task interposed between two resting state sessions. Memory performance was assessed through a forced-choice recognition test after the scanning sessions. We investigated resting state system configuration changes via Independent Component Analysis by cross-modeling baseline resting state spatial maps onto the post-encoding resting state, and post-encoding resting state spatial maps onto baseline. We identified both persistent and plastic components of the overall brain functional configuration between baseline and post-encoding. While FC patterns within executive, default mode, and cerebellar circuits persisted from baseline to post-encoding, FC within the visual circuit changed. A significant session × performance interaction characterized medial temporal lobe and prefrontal cortex FC with the visual circuit, as well as thalamic FC within the executive control system. Findings reveal early-stage FC changes at the system-level subsequent to a learning experience and associated with inter-individual variation in memory performance.
KW - Episodic memory
KW - Functional connectivity
KW - Independent component analysis
KW - Learning
KW - Resting state
KW - System configuration
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U2 - 10.1016/j.neuroimage.2021.118636
DO - 10.1016/j.neuroimage.2021.118636
M3 - Article
C2 - 34637904
AN - SCOPUS:85117152889
SN - 1053-8119
VL - 245
JO - NeuroImage
JF - NeuroImage
M1 - 118636
ER -