How microRNAs influence both hereditary and inflammatory-mediated colon cancers

Jennifer Hutchison, Zoe Cohen, Benjamin C. Onyeagucha, Janet Funk, Mark A. Nelson

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


MicroRNAs have emerged as important post-translational regulators of gene expression and are involved in several physiological and pathological states including the pathogenesis of human colon cancers. In regards to tumor development, microRNAs can act as oncogenes or tumor suppressors. Two hereditary predispositions (i.e., Lynch syndrome and familial adenomatous polyposis) contribute to the development of colon cancer. In addition, individuals who suffer from inflammatory bowel diseases such as Crohn's disease or ulcerative colitis have a higher risk of developing colon cancer. Here, we discuss the occurrence of the deregulated expression of microRNAs in colon cancer that arise as a result of hereditary predisposition and inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)309-316
Number of pages8
JournalCancer Genetics
Issue number9-10
StatePublished - Sep 2013


  • Crohn's disease
  • FAP
  • MicroRNA
  • Ulcerative colitis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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