Host Range of Chlamydiaphages φCPAR39 and Chp3

J. S. Everson, S. A. Garner, P. R. Lambden, B. A. Fane, I. N. Clarke

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The host range of φCPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that φCPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.

Original languageEnglish (US)
Pages (from-to)6490-6492
Number of pages3
JournalJournal of bacteriology
Volume185
Issue number21
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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