Hormones, Cognition and Dementia: State of the art and emergent therapeutic strategies

Eef Hogervorst, Victor W. Henderson, Robert B. Gibbs, Roberta Diaz Brinton

Research output: Book/ReportBook

12 Scopus citations

Abstract

A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.

Original languageEnglish (US)
PublisherCambridge University Press
Number of pages282
ISBN (Electronic)9780511635700
ISBN (Print)9780521899376
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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