Hormonal regulation of medial preoptic µ-opiate receptor density before and after parturition

Ronald P. Hammer, Annabelle R. Mateo, Robert S. Bridges

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Endogenous opioid peptides acting in the medial preoptic area (MPOA) appear to be involved in the regulation of maternal behavior in lactating rats. Moreover, it is known that the density of µ-opiate receptors in the MPOA is elevated during pregnancy, but decreases during lactation. In the first experiment of this study, µ-receptor density in the preoptic area was examined across the periparturitional period on gestation days 18, 20 and 22, at 1 h postpartum and on postpartum days 1 and 12. The effect of pregnancy during lactation on µ-receptor density was also assessed. In addition, plasma hormone concentration of estradiol (E2), progesterone (P), and prolactin (PRL) were determined. While plasma P levels decreased and PRL levels increased prior to parturition, MPOA µ receptor density remained elevated until 24 h after parturition before declining to reach a level similar to that of ovariectomized control animals. Receptor density was significantly correlated with PRL levels only in gestation day 22 animals, when PRL levels were highest. MPOA [µ-receptor density was low at postpartum day 12 whether or not the animal was pregnant. No effects were observed in the adjacent lateral preoptic area in any group. In the second experiment, the effect of hormonal manipulation on preoptic opiate receptor density was examined at various times after removal of Silastic capsules containing P following sustained E2/P exposure. While P levels decreased abruptly following capsule removal, MPOA receptor density declined more gradually. The results are consistent with the hypothesis that a reduction of u-receptor density occurs in the MPOA following parturition by receptor turnover in the absence of sufficient hormonal stimulation. This apparent reduction of the substrate for MPOA opioid activity could be related to the postparturitional events associated with lactation, since µ-receptor density is reduced even in pregnant, lactating rats.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
Issue number1
StatePublished - 1992


  • Lactation
  • Maternal behavior
  • Medial preoptic area
  • Opioid
  • Pregnancy
  • Progesterone
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Hormonal regulation of medial preoptic µ-opiate receptor density before and after parturition'. Together they form a unique fingerprint.

Cite this