Homologous recombination in negative sense RNA viruses

Guan Zhu Han, Michael Worobey

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.

Original languageEnglish (US)
Pages (from-to)1358-1373
Number of pages16
Issue number8
StatePublished - Aug 2011


  • Evolution
  • Homologous recombination
  • Negative sense RNA viruses

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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