Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals

Eugene A. Mash; Susan B. Hemperly

doi:10.1016/S0040-4039(00)80410-4

Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals

Eugene A. Mash
, Susan B. Hemperly

Chemistry & Biochemistry - Sci

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A general method for the chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals derived from 1,4-di-O-benzyl-L-threitol is reported. Separability is thought to result from differences in intramolecular hydrogen bonding for the two diastereomeric forms.

Original language	English (US)
Pages (from-to)	4035-4038
Number of pages	4
Journal	Tetrahedron Letters
Volume	29
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4039(00)80410-4
State	Published - 1988

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)80410-4

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@article{457a4c7afa044445aaf0a842b83cb308,

title = "Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals",

abstract = "A general method for the chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals derived from 1,4-di-O-benzyl-L-threitol is reported. Separability is thought to result from differences in intramolecular hydrogen bonding for the two diastereomeric forms.",

author = "Mash, \{Eugene A.\} and Hemperly, \{Susan B.\}",

note = "Funding Information: 4 4 4 Acknovledgemenint madet o the donors of the Petrolem ResearchF und. lb iniatered by the AmericanC hemicalS ociety, for support of this research. Partial support of this research by the AmericanH eart Association, Arizona Affiliate, and by the University of Arizona Foundation and the Office of the Vice President for Reaeerch, is gratefully acknowledged.",

year = "1988",

doi = "10.1016/S0040-4039(00)80410-4",

language = "English (US)",

volume = "29",

pages = "4035--4038",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "33",

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TY - JOUR

T1 - Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals

AU - Mash, Eugene A.

AU - Hemperly, Susan B.

N1 - Funding Information: 4 4 4 Acknovledgemenint madet o the donors of the Petrolem ResearchF und. lb iniatered by the AmericanC hemicalS ociety, for support of this research. Partial support of this research by the AmericanH eart Association, Arizona Affiliate, and by the University of Arizona Foundation and the Office of the Vice President for Reaeerch, is gratefully acknowledged.

PY - 1988

Y1 - 1988

N2 - A general method for the chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals derived from 1,4-di-O-benzyl-L-threitol is reported. Separability is thought to result from differences in intramolecular hydrogen bonding for the two diastereomeric forms.

AB - A general method for the chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals derived from 1,4-di-O-benzyl-L-threitol is reported. Separability is thought to result from differences in intramolecular hydrogen bonding for the two diastereomeric forms.

UR - https://www.scopus.com/pages/publications/1542447274

UR - https://www.scopus.com/pages/publications/1542447274#tab=citedBy

U2 - 10.1016/S0040-4039(00)80410-4

DO - 10.1016/S0040-4039(00)80410-4

M3 - Article

AN - SCOPUS:1542447274

SN - 0040-4039

VL - 29

SP - 4035

EP - 4038

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals

Abstract

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