Homeostatic plasticity drives tinnitus perception in an animal model

Sungchil Yang, Benjamin D. Weiner, Li S. Zhang, Sung Jin Cho, Shaowen Bao

Research output: Contribution to journalArticlepeer-review

189 Scopus citations

Abstract

Hearing loss often results in tinnitus and auditory cortical map changes, leading to the prevailing view that the phantom perception is associated with cortical reorganization. However, we show here that tinnitus is mediated by a cortical area lacking map reorganization. High-frequency hearing loss results in two distinct cortical regions: a sensory-deprived region characterized by a decrease in inhibitory synaptic transmission and a normal hearing region showing increases in inhibitory and excitatory transmission and map reorganization. Hearing-lesioned animals displayed tinnitus with a pitch in the hearing loss range. Furthermore, drugs that enhance inhibition, but not those that reduce excitation, reversibly eliminated the tinnitus behavior. These results suggest that sensory deprivation-induced homeostatic down-regulation of inhibitory synapses may contribute to tinnitus perception. Enhancing sensory input through map reorganization may plausibly alleviate phantom sensation.

Original languageEnglish (US)
Pages (from-to)14974-14979
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number36
DOIs
StatePublished - Sep 6 2011
Externally publishedYes

Keywords

  • Auditory cortex
  • Deafness
  • GABA
  • Phantom pain
  • Tonic inhibition

ASJC Scopus subject areas

  • General

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