Homeostatic mechanisms and treatment of tinnitus

Sungchil Yang, Shaowen Bao

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Tinnitus, the phantom percept of sound, is a potentially debilitating disorder affecting up to ten percent of the general population. After decades of effort, we still lack an effective treatment for tinnitus, partly because of its diverse underlying etiology. Recent studies have yielded hypotheses for central mechanisms underlying hearing loss-induced tinnitus, the most common form of tinnitus. Here we review recent evidence that homeostatic down-regulation of phasic and tonic inhibition is a mechanism underlying hearing loss-induced tinnitus. We propose to treat tinnitus through novel strategies of sensory training and targeted pharmacological intervention to reverse the homeostatic changes induced by hearing loss.

Original languageEnglish (US)
Pages (from-to)99-108
Number of pages10
JournalRestorative Neurology and Neuroscience
Volume31
Issue number2
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Phantom percept
  • acoustic trauma
  • map reorganization
  • rehabilitation

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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