HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Jussara Amato; Thushara W. Madanayake; Nunzia Iaccarino; Ettore Novellino; Antonio Randazzo; Laurence H. Hurley; Bruno Pagano

doi:10.1039/c8cc03614d

HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Jussara Amato, Thushara W. Madanayake, Nunzia Iaccarino, Ettore Novellino, Antonio Randazzo, Laurence H. Hurley, Bruno Pagano

Pharmacology and Toxicology

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46 Scopus citations

Abstract

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

Original language	English (US)
Pages (from-to)	9442-9445
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	68
DOIs	https://doi.org/10.1039/c8cc03614d
State	Published - Jan 1 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?",

abstract = "This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.",

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AU - Amato, Jussara

AU - Madanayake, Thushara W.

AU - Iaccarino, Nunzia

AU - Novellino, Ettore

AU - Randazzo, Antonio

AU - Hurley, Laurence H.

AU - Pagano, Bruno

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N2 - This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

AB - This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

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HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

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