HLA-DR (Ia) immune phenotype predicts outcome for patients with diffuse large cell lymphoma

T. P. Miller, S. M. Lippman, C. M. Spier, D. J. Slymen, T. M. Grogan

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


The clinical utility for establishing the immune phenotype in patients with non-Hodgkin's lymphoma is controversial. To help resolve this dilemma, we studied 104 consecutive patients with diffuse large cell lymphoma, the most common subtype of potentially curable non-Hodgkin's lymphomas. The presence or absence of the human class II histocompatibility antigen was determined using the monoclonal antibody anti-HLA-DR (Ia), and the results correlated with pretreatment clinical features and survival. We found that eight HLA-DR negative patients had similar pretreatment clinical characteristics compared with 96 HLA-DR positive patients, but HLA-DR negative patients had a significantly shorter survival duration compared with HLA-DR positive patients (P = 0.003 log-rank). The median survival of the HLA-DR negative patients was 0.5 years compared to 2.8 yr for the HLA-DR positive patients. No HLA-DR negative patient survived beyond 1.5 yr. A multivariate analysis, adjusting for prognostic factors of known clinical significance, confirmed the importance of HLA-DR as a prognostic factor (P = 0.016). We conclude that determining the presence of HLA-DR is a relatively simple pretreatment study that identifies a small but important group of patients who are not curable using currently available combination chemotherapy.

Original languageEnglish (US)
Pages (from-to)370-372
Number of pages3
JournalJournal of Clinical Investigation
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Medicine(all)


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