HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age

R. C. Williams; W. C. Knowler; W. J. Butler; D. J. Pettitt; J. R. Lisse; P. H. Bennett; D. L. Mann; A. H. Johnson; P. I. Terasaki

doi:10.1007/BF00257786

HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age

R. C. Williams, W. C. Knowler, W. J. Butler, D. J. Pettitt, J. R. Lisse, P. H. Bennett, D. L. Mann, A. H. Johnson, P. I. Terasaki

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46 Scopus citations

Abstract

In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).

Original language	English (US)
Pages (from-to)	460-463
Number of pages	4
Journal	Diabetologia
Volume	21
Issue number	5
DOIs	https://doi.org/10.1007/BF00257786
State	Published - Nov 1981
Externally published	Yes

Keywords

HLA-A2
Pima Indians
Type 2 diabetes
age association
diabetes
genetics

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/BF00257786

Cite this

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title = "HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age",

abstract = "In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).",

keywords = "HLA-A2, Pima Indians, Type 2 diabetes, age association, diabetes, genetics",

author = "Williams, {R. C.} and Knowler, {W. C.} and Butler, {W. J.} and Pettitt, {D. J.} and Lisse, {J. R.} and Bennett, {P. H.} and Mann, {D. L.} and Johnson, {A. H.} and Terasaki, {P. I.}",

year = "1981",

month = nov,

doi = "10.1007/BF00257786",

language = "English (US)",

volume = "21",

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journal = "Diabetologia",

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TY - JOUR

T1 - HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians

T2 - An association of allele frequency with age

AU - Williams, R. C.

AU - Knowler, W. C.

AU - Butler, W. J.

AU - Pettitt, D. J.

AU - Lisse, J. R.

AU - Bennett, P. H.

AU - Mann, D. L.

AU - Johnson, A. H.

AU - Terasaki, P. I.

PY - 1981/11

Y1 - 1981/11

N2 - In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).

AB - In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).

KW - HLA-A2

KW - Pima Indians

KW - Type 2 diabetes

KW - age association

KW - diabetes

KW - genetics

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HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age

Abstract

Keywords

ASJC Scopus subject areas

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