HIV-related lung disorders

Homer L. Twigg, Kenneth S. Knox

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Highly active antiretroviral therapy (HAART) has dramatically altered the spectrum of morbidity and mortality in HIV-infected patients. This has been attributed to improvements in the lung microenvironment leading to enhanced pulmonary immunity, either by preventing the progressive loss of immune function or by actually promoting immune restoration. However, these changes have been accompanied by the recognition of new pulmonary complications in HIV-infected subjects, especially those associated with immune reconstitution. In this review, we will describe how HIV infection alters the normal pulmonary environment, highlight the effect of HAART on these perturbations and discuss potential complications of HAART in the lung, focusing on the pulmonary immune reconstitution inflammatory syndrome (IRIS).

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Issue number2
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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