TY - JOUR
T1 - History of Infertility and Risk of Colorectal Cancer
AU - Farland, Leslie V.
AU - Lind, Kimberly E.
AU - Roe, Denise J.
AU - Saquib, Nazmus
AU - Strickler, Howard D.
AU - Qi, Lihong
AU - Thomson, Cynthia A.
AU - Harris, Holly R.
N1 - Publisher Copyright:
©2024 American Association for Cancer Research.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Background: There has been limited prior research on the association between infertility and risk of colorectal cancer. Methods: Data from postmenopausal women in the Women’s Health Initiative were used to estimate the association between self-reported infertility (12 months of trying to get pregnant without achieving a pregnancy) and the risk of colorectal cancer using Cox proportional hazard models. Results: No association was observed between infertility and risk of postmenopausal colorectal cancer [RR, 0.97; 95% confidence interval (CI), 0.87–1.08], invasive colorectal cancer (RR, 0.99; 95% CI, 0.88–1.10), or colorectal cancer mortality (RR, 0.89; 95% CI, 0.71–1.12). Conclusions: Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses. Impact: Infertility may not be associated with colorectal cancer risk.
AB - Background: There has been limited prior research on the association between infertility and risk of colorectal cancer. Methods: Data from postmenopausal women in the Women’s Health Initiative were used to estimate the association between self-reported infertility (12 months of trying to get pregnant without achieving a pregnancy) and the risk of colorectal cancer using Cox proportional hazard models. Results: No association was observed between infertility and risk of postmenopausal colorectal cancer [RR, 0.97; 95% confidence interval (CI), 0.87–1.08], invasive colorectal cancer (RR, 0.99; 95% CI, 0.88–1.10), or colorectal cancer mortality (RR, 0.89; 95% CI, 0.71–1.12). Conclusions: Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses. Impact: Infertility may not be associated with colorectal cancer risk.
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U2 - 10.1158/1055-9965.EPI-24-0313
DO - 10.1158/1055-9965.EPI-24-0313
M3 - Article
C2 - 38787308
AN - SCOPUS:85200423897
SN - 1055-9965
VL - 33
SP - 1129
EP - 1131
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 8
ER -