History of cancer and fertility treatment outcomes: a registry linkage study in Massachusetts

Leslie V. Farland, Judy E. Stern, Sunah S. Hwang, Chia ling Liu, Howard Cabral, Richard Knowlton, Susan T. Gershman, Charles C. Coddington, Stacey A. Missmer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To investigate assisted reproductive technology (ART) outcomes among adolescent and young-adult female cancer survivors. Methods: The Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) data were linked to the Massachusetts Cancer Registry for 90,928 ART cycles in Massachusetts to women ≥ 18 years old from 2004 to 2013. To estimate relative risks (RR) and 95% confidence intervals (CI), we used generalized estimating equations with a log link that accounted for multiple cycles per woman and a priori adjusted for maternal age and cycle year. The main outcomes of interest were ART treatment patterns; number of autologous oocytes retrieved, fertilized, and transferred; and rates of implantation, clinical intrauterine gestation (CIG), live birth, and pregnancy loss. Results: We saw no difference in number of oocytes retrieved (aRR: 0.95 (0.89–1.02)) or proportion of autologous oocytes fertilized (aRR: 0.99 (0.95–1.03)) between autologous cycles with and without a history of cancer; however, cancer survivors required a higher total FSH administered (aRR: 1.12 (1.06–1.19)). Among autologous cycle starts, cycles in women with a history of cancer were less likely to result in CIG compared to no history of cancer (aRR: 0.73 (0.65–0.83)); this relationship was absent from donor cycles (aRR: 1.01 (0.85–1.20)). Once achieving CIG, donor cycles for women with a history of cancer were two times more likely to result in pregnancy loss (aRR: 1.99 (1.26–3.16)). Conclusions: Our analysis suggests that cancer may influence ovarian stimulation response, requiring more FSH and resulting in lower CIG among cycle starts.

Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalJournal of Assisted Reproduction and Genetics
Issue number2
StatePublished - Feb 2022


  • ART
  • Cancer
  • Infertility
  • Survivorship

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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