Histoplasmosis-associated cross-reactivity in the biorad platelia Aspergillus enzyme immunoassay

L. Joseph Wheat; Emily Hackett; Michelle Durkin; Patricia Connolly; Ruta Petraitiene; Thomas J. Walsh; Kenneth Knox; Chadi Hage

doi:10.1128/CVI.00479-06

Histoplasmosis-associated cross-reactivity in the biorad platelia Aspergillus enzyme immunoassay

L. Joseph Wheat, Emily Hackett, Michelle Durkin, Patricia Connolly, Ruta Petraitiene, Thomas J. Walsh, Kenneth Knox, Chadi Hage

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

Original language	English (US)
Pages (from-to)	638-640
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	14
Issue number	5
DOIs	https://doi.org/10.1128/CVI.00479-06
State	Published - May 2007

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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abstract = "We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.",

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AU - Wheat, L. Joseph

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AU - Durkin, Michelle

AU - Connolly, Patricia

AU - Petraitiene, Ruta

AU - Walsh, Thomas J.

AU - Knox, Kenneth

AU - Hage, Chadi

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N2 - We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

AB - We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

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Histoplasmosis-associated cross-reactivity in the biorad platelia Aspergillus enzyme immunoassay

Abstract

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