Histopathology of optic nerve pit-associated maculopathy

John B. Christoforidis, William Terrell, Frederick H. Davidorf

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous elevation of the macula and cavernous atrophy of the optic nerve. Methods: An eye bank specimen found to have an optic nerve pit with serous elevation of the macula was grossly examined and photographed. The globe was processed for both light and scanning electron microscopy. Results: The scanning electron microscopic study of this eye with an optic nerve pit revealed holes in the diaphanous membrane overlying the nerve at the edge of the optic pit. Serial histopathology sections revealed a connection between the holes overlying the optic pit and the subretinal space via a schisis-like cavity in the retina. Conclusion: The discovery of an optic nerve pit with coexisting serous detachment of the macula in an eye bank eye and subsequent pathological evaluation provides support for current theories into the mechanism of the visual loss in this condition. Our finding supports syneretic vitreous to be the source of the subretinal fluid.

Original languageEnglish (US)
Pages (from-to)1169-1174
Number of pages6
JournalClinical Ophthalmology
Issue number1
StatePublished - Jul 24 2012


  • Electron microscopy
  • Light microscopy
  • Optic nerve pit
  • Retinal detachment

ASJC Scopus subject areas

  • Ophthalmology


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