Histone genes are clustered with a 15-kilobas repeat in the chicken genome

R. J. Crawford; P. Krieg; R. P. Harvey; D. A. Hewish; J. R.E. Wells

doi:10.1038/279132a0

Histone genes are clustered with a 15-kilobas repeat in the chicken genome

R. J. Crawford, P. Krieg, R. P. Harvey, D. A. Hewish, J. R.E. Wells

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.

Original language	English (US)
Pages (from-to)	132-136
Number of pages	5
Journal	Nature
Volume	279
Issue number	5709
DOIs	https://doi.org/10.1038/279132a0
State	Published - 1979

ASJC Scopus subject areas

General

Access to Document

10.1038/279132a0

Cite this

@article{d488aeb8251d4bdb9cc124cc0242ddc5,

title = "Histone genes are clustered with a 15-kilobas repeat in the chicken genome",

abstract = "Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.",

author = "Crawford, {R. J.} and P. Krieg and Harvey, {R. P.} and Hewish, {D. A.} and Wells, {J. R.E.}",

year = "1979",

doi = "10.1038/279132a0",

language = "English (US)",

volume = "279",

pages = "132--136",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5709",

}

TY - JOUR

T1 - Histone genes are clustered with a 15-kilobas repeat in the chicken genome

AU - Crawford, R. J.

AU - Krieg, P.

AU - Harvey, R. P.

AU - Hewish, D. A.

AU - Wells, J. R.E.

PY - 1979

Y1 - 1979

N2 - Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.

AB - Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.

UR - http://www.scopus.com/inward/record.url?scp=0018399780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018399780&partnerID=8YFLogxK

U2 - 10.1038/279132a0

DO - 10.1038/279132a0

M3 - Article

C2 - 440417

AN - SCOPUS:0018399780

SN - 0028-0836

VL - 279

SP - 132

EP - 136

JO - Nature

JF - Nature

IS - 5709

ER -

Histone genes are clustered with a 15-kilobas repeat in the chicken genome

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this