Histochemical and ultrastructural features of an unusual pulmonary carcinosarcoma

Kent G. Zimmerman, Richard E. Sobonya, Claire M. Payne

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


An autopsy case is presented in which a pulmonary carcinosarcoma filled the left chest of a 61 year old man. The extensive pleural involvement that this neoplasm exhibited has not been reported previously. By light microscopy the neoplasm initially was considered a mesothelioma because of the pattern of glands and undifferentiated sarcomatous stroma. However, by electron microscopy the sarcomatous component was found to show rhabdomyoblastic differentiation. Neither histochemical stains nor electron microscopy supported a mesothelial origin for the glandular component. Differential diagnostic considerations of pleuropulmonary neoplasms showing rhabdomyosarcomatous differentiation are discussed. This case illustrates the importance of detailed study in order to characterize and properly classify these neoplasms.

Original languageEnglish (US)
Pages (from-to)1046-1051
Number of pages6
JournalHuman pathology
Issue number11
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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