Highly stereoselective synthesis of aryl/heteroaryl-: C -nucleosides via the merger of photoredox and nickel catalysis

Yingying Ma; Shihui Liu; Yifan Xi; Hongrui Li; Kai Yang; Zhihao Cheng; Wei Wang; Yongqiang Zhang

doi:10.1039/c9cc07184a

Highly stereoselective synthesis of aryl/heteroaryl-: C -nucleosides via the merger of photoredox and nickel catalysis

Yingying Ma, Shihui Liu, Yifan Xi, Hongrui Li, Kai Yang, Zhihao Cheng, Wei Wang, Yongqiang Zhang

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.

Original language	English (US)
Pages (from-to)	14657-14660
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	97
DOIs	https://doi.org/10.1039/c9cc07184a
State	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc07184a

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abstract = "A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.",

author = "Yingying Ma and Shihui Liu and Yifan Xi and Hongrui Li and Kai Yang and Zhihao Cheng and Wei Wang and Yongqiang Zhang",

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T1 - Highly stereoselective synthesis of aryl/heteroaryl-

T2 - C -nucleosides via the merger of photoredox and nickel catalysis

AU - Ma, Yingying

AU - Liu, Shihui

AU - Xi, Yifan

AU - Li, Hongrui

AU - Yang, Kai

AU - Cheng, Zhihao

AU - Wang, Wei

AU - Zhang, Yongqiang

PY - 2019

Y1 - 2019

N2 - A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.

AB - A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Highly stereoselective synthesis of aryl/heteroaryl-: C -nucleosides via the merger of photoredox and nickel catalysis

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ASJC Scopus subject areas

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