@article{843f0dfb192e4530842fddcc43a8923f,
title = "Highly Stable Meldrum's Acid Derivatives for Irreversible Aqueous Covalent Modification of Amines",
abstract = "This work describes the development of a highly stable and pH-responsive probe for lysine modification. The scaffold has marked stability in the presence of several biological nucleophiles and across a wide pH range (2-12). Several functional analogs showed robust labeling of a protein at pH > 9. Taken together, our system displays versatility and can be easily adapted for variety of applications, while demonstrating stability suitable for a wide range of biologically compatible systems.",
author = "Davis, {Garrett J.} and Sofka, {Holly A.} and Jewett, {John C.}",
note = "Funding Information: This work was supported in part by a NSF-Career Award to J.C.J. (CHE-1552568). H.A.S. received support from Graduate Access Fellowship and NIH Training Grant (T32 GM008804). All FTIR spectra were collected in the W. M. Keck Center for Nano-Scale Imaging in the Department of Chemistry and Biochemistry at the University of Arizona, purchased with support by the Arizona Technology and Research Initiative Fund (A.R.S.§15-1648). We also thank the NSF for a departmental instrumentation grant for the NMR facility (CHE-0840336). Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",
year = "2020",
month = apr,
day = "3",
doi = "10.1021/acs.orglett.0c00597",
language = "English (US)",
volume = "22",
pages = "2626--2629",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "7",
}