TY - JOUR
T1 - Highly enantioselective organocatalytic conjugate addition of nitromethane to α,β-unsaturated aldehydes
T2 - Three-step synthesis of optically active baclofen
AU - Zu, Liansuo
AU - Xie, Hexin
AU - Li, Hao
AU - Wang, Jian
AU - Wang, Wei
PY - 2007/12
Y1 - 2007/12
N2 - An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.
AB - An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.
KW - Asymmetric catalysis
KW - Asymmetric synthesis
KW - C-C bond formation
KW - Michael addition
KW - Organic catalysis
UR - http://www.scopus.com/inward/record.url?scp=37349109188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37349109188&partnerID=8YFLogxK
U2 - 10.1002/adsc.200700353
DO - 10.1002/adsc.200700353
M3 - Article
AN - SCOPUS:37349109188
SN - 1615-4150
VL - 349
SP - 2660
EP - 2664
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 17-18
ER -