Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

Chenguang Yu, Yinan Zhang, Shilei Zhang, Jing He, Wei Wang

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes.

Original languageEnglish (US)
Pages (from-to)1742-1744
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number13
DOIs
StatePublished - Mar 31 2010
Externally publishedYes

Keywords

  • Cascade
  • Michael
  • Organocatalysis
  • Pd catalysis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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