Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

Chenguang Yu; Yinan Zhang; Shilei Zhang; Jing He; Wei Wang

doi:10.1016/j.tetlet.2010.01.096

Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

Chenguang Yu, Yinan Zhang, Shilei Zhang, Jing He, Wei Wang

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes.

Original language	English (US)
Pages (from-to)	1742-1744
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2010.01.096
State	Published - Mar 31 2010
Externally published	Yes

Keywords

Cascade
Michael
Organocatalysis
Pd catalysis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.01.096

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title = "Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis",

abstract = "The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes.",

keywords = "Cascade, Michael, Organocatalysis, Pd catalysis",

author = "Chenguang Yu and Yinan Zhang and Shilei Zhang and Jing He and Wei Wang",

year = "2010",

month = mar,

day = "31",

doi = "10.1016/j.tetlet.2010.01.096",

language = "English (US)",

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T1 - Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

AU - Yu, Chenguang

AU - Zhang, Yinan

AU - Zhang, Shilei

AU - He, Jing

AU - Wang, Wei

PY - 2010/3/31

Y1 - 2010/3/31

N2 - The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes.

AB - The novel dual cooperative asymmetric aminocatalysis and Lewis acid catalysis has been successfully developed for promoting cascade Michael-cyclization reaction with high enantio-, regio- and chemo-selectivity. The simple and practical process affords a one-pot approach to synthetically useful cyclopentenes.

KW - Cascade

KW - Michael

KW - Organocatalysis

KW - Pd catalysis

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DO - 10.1016/j.tetlet.2010.01.096

M3 - Article

AN - SCOPUS:76949089685

SN - 0040-4039

VL - 51

SP - 1742

EP - 1744

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 13

ER -

Highly enantioselective Michael-cyclization cascade promoted by synergistic asymmetric aminocatalysis and Lewis acid catalysis

Abstract

Keywords

ASJC Scopus subject areas

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