Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water

Liansuo Zu; Hexin Xie; Hao Li; Jian Wang; Wei Wang

doi:10.1021/ol800074z

Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water

Liansuo Zu, Hexin Xie, Hao Li, Jian Wang, Wei Wang

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the organo catalyst is that it can be recovered from the reaction mixtures by simple fluorous solid-phase extraction and subsequently reused (up to seven cycles) without a significant loss of catalytic activity and stereoselectivity.

Original language	English (US)
Pages (from-to)	1211-1214
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	6
DOIs	https://doi.org/10.1021/ol800074z
State	Published - Mar 20 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the organo catalyst is that it can be recovered from the reaction mixtures by simple fluorous solid-phase extraction and subsequently reused (up to seven cycles) without a significant loss of catalytic activity and stereoselectivity.",

author = "Liansuo Zu and Hexin Xie and Hao Li and Jian Wang and Wei Wang",

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T1 - Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water

AU - Zu, Liansuo

AU - Xie, Hexin

AU - Li, Hao

AU - Wang, Jian

AU - Wang, Wei

PY - 2008/3/20

Y1 - 2008/3/20

N2 - Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the organo catalyst is that it can be recovered from the reaction mixtures by simple fluorous solid-phase extraction and subsequently reused (up to seven cycles) without a significant loss of catalytic activity and stereoselectivity.

AB - Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the organo catalyst is that it can be recovered from the reaction mixtures by simple fluorous solid-phase extraction and subsequently reused (up to seven cycles) without a significant loss of catalytic activity and stereoselectivity.

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JF - Organic Letters

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ER -

Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water

Abstract

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