Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water

Liansuo Zu, Hexin Xie, Hao Li, Jian Wang, Wei Wang

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the organo catalyst is that it can be recovered from the reaction mixtures by simple fluorous solid-phase extraction and subsequently reused (up to seven cycles) without a significant loss of catalytic activity and stereoselectivity.

Original languageEnglish (US)
Pages (from-to)1211-1214
Number of pages4
JournalOrganic Letters
Volume10
Issue number6
DOIs
StatePublished - Mar 20 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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