High-transmission-efficiency and side-viewing micro OIDRS probe for fast and minimally invasive tumor margin detection

Alejandro Garcia-Uribe; Cheng Chung Chang; Murat Kaya Yapici; Jun Zou; Bhaskar Banerjee; John Kuczynski; Evan S. Ong; Erin S. Marner; Lihong V. Wang

doi:10.1109/JSEN.2010.2076279

High-transmission-efficiency and side-viewing micro OIDRS probe for fast and minimally invasive tumor margin detection

Alejandro Garcia-Uribe, Cheng Chung Chang, Murat Kaya Yapici, Jun Zou, Bhaskar Banerjee, John Kuczynski, Evan S. Ong, Erin S. Marner, Lihong V. Wang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

Original language	English (US)
Article number	5585661
Pages (from-to)	891-896
Number of pages	6
Journal	IEEE Sensors Journal
Volume	11
Issue number	4
DOIs	https://doi.org/10.1109/JSEN.2010.2076279
State	Published - Apr 1 2011

Keywords

Diffuse reflectance
microoptical probe
oblique incidence
pancreatic cancer
spectroscopy
tumor margin

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

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10.1109/JSEN.2010.2076279

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title = "High-transmission-efficiency and side-viewing micro OIDRS probe for fast and minimally invasive tumor margin detection",

abstract = "The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with {"}side-viewing{"} capability. Its unprecedented small size, unique {"}side-viewing{"} capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.",

keywords = "Diffuse reflectance, microoptical probe, oblique incidence, pancreatic cancer, spectroscopy, tumor margin",

author = "Alejandro Garcia-Uribe and Chang, {Cheng Chung} and Yapici, {Murat Kaya} and Jun Zou and Bhaskar Banerjee and John Kuczynski and Ong, {Evan S.} and Marner, {Erin S.} and Wang, {Lihong V.}",

note = "Funding Information: Manuscript received April 26, 2010; revised July 05, 2010; accepted August 20, 2010. Date of publication September 27, 2010; date of current version February 04, 2011. This work was supported by the National Institute of Health under Grant R01 CA106728. The associate editor coordinating the review of this paper and approving it for publication was Prof. Okyay Kaynak.",

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AU - Garcia-Uribe, Alejandro

AU - Chang, Cheng Chung

AU - Yapici, Murat Kaya

AU - Zou, Jun

AU - Banerjee, Bhaskar

AU - Kuczynski, John

AU - Ong, Evan S.

AU - Marner, Erin S.

AU - Wang, Lihong V.

N1 - Funding Information: Manuscript received April 26, 2010; revised July 05, 2010; accepted August 20, 2010. Date of publication September 27, 2010; date of current version February 04, 2011. This work was supported by the National Institute of Health under Grant R01 CA106728. The associate editor coordinating the review of this paper and approving it for publication was Prof. Okyay Kaynak.

PY - 2011/4/1

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N2 - The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

AB - The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

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High-transmission-efficiency and side-viewing micro OIDRS probe for fast and minimally invasive tumor margin detection

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Keywords

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