High-throughput, multiplexed pushbroom hyperspectral microscopy

M. E. Gehm; M. S. Kim; C. Fernandez; D. J. Brady

doi:10.1364/OE.16.011032

High-throughput, multiplexed pushbroom hyperspectral microscopy

M. E. Gehm, M. S. Kim, C. Fernandez, D. J. Brady

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We describe a high-throughput hyperspectral microscope. The system replaces the slit of conventional pushbroom spectral imagers with a static coded aperture mask. We present the theoretical underpinnings of the aperture coded spectral engine and describe two proof-of-concept experimental implementations. Compared to a conventional pushbroom system, the aperture coded systems have 32 times greater throughput. Both systems have about a 1nm spectral resolution over the spectral range of 550-665nm. For the first design, the spatial resolution for the system is 5.4μm, while the spatial resolution for the second system ranges from 7.7μm to 1.54μm. We describe experimental results from proof-of-concept applications of the imager to hyperspectral microscopy.

Original language	English (US)
Pages (from-to)	11032-11043
Number of pages	12
Journal	Optics Express
Volume	16
Issue number	15
DOIs	https://doi.org/10.1364/OE.16.011032
State	Published - Jul 21 2008
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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AB - We describe a high-throughput hyperspectral microscope. The system replaces the slit of conventional pushbroom spectral imagers with a static coded aperture mask. We present the theoretical underpinnings of the aperture coded spectral engine and describe two proof-of-concept experimental implementations. Compared to a conventional pushbroom system, the aperture coded systems have 32 times greater throughput. Both systems have about a 1nm spectral resolution over the spectral range of 550-665nm. For the first design, the spatial resolution for the system is 5.4μm, while the spatial resolution for the second system ranges from 7.7μm to 1.54μm. We describe experimental results from proof-of-concept applications of the imager to hyperspectral microscopy.

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High-throughput, multiplexed pushbroom hyperspectral microscopy

Abstract

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