High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects

Umit Yoruk, Manojkumar Saranathan, Andreas M. Loening, Brian A. Hargreaves, Shreyas S. Vasanawala

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose To introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input function (HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children. Methods A high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images. Results Digital phantom simulations showed that using the HTR-AIF technique gives more accurate AIF estimates (RMSE = 0.0932) compared with the existing estimation method (RMSE = 0.2059) that used view-sharing (VS). For simulated GFR > 27 mL/min, GFR estimation error was between 32% and 17% using view-shared AIF, whereas estimation error was less than 10% using HTR-AIF. In all clinical subjects, the HTR-AIF method resulted in higher GFR estimations than the view-shared method. Conclusion The HTR-AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory-gated acquisitions, and makes GFR estimation feasible in free-breathing pediatric subjects.

Original languageEnglish (US)
Pages (from-to)1301-1311
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • arterial input function estimation
  • dynamic contrast enhancement
  • glomerular filtration rate estimation
  • high spatiotemporal resolution dynamic imaging
  • urography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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