High-sensitivity C-reactive protein in stroke patients – The importance in consideration of influence of multiple factors in the predictability for disease severity and death

Hong Yu, Yue Huang, Xin Yu Chen, Wen Bao Nie, Yong Jun Wang, Yan Jiao, Guy L. Reed, Weikuan Gu, Hong Chen

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

High sensitivity C-reactive protein (hsCRP) has been evaluated as a biomarker in stroke and relevant pathological diseases. While its predictive values in several pathological phenotypes have been confirmed, controversy exists among different studies. This review summarizes reports of the predictive values of hsCRP for the diagnosis, etiology, prognosis and mortality of stroke diseases. The current literature suggests that CRP expression is influenced by multiple factors, such as polymorphisms, the genomic backgrounds and gender. However, few reported studies analyzed data based on all these multiple factors. Future studies should focus on comprehensive analysis based on multiple factors.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalJournal of Clinical Neuroscience
Volume36
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Keywords

  • Atherosclerosis
  • High sensitivity C-reactive protein (hsCRP)
  • Ischemic
  • Polymorphism
  • Predictability
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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