High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Don Hayes; Karen S. McCoy; Bryan A. Whitson; Heidi M. Mansour; Joseph D. Tobias

doi:10.1111/petr.12401

High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Don Hayes, Karen S. McCoy, Bryan A. Whitson, Heidi M. Mansour, Joseph D. Tobias

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.

Original language	English (US)
Pages (from-to)	206-210
Number of pages	5
Journal	Pediatric transplantation
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/petr.12401
State	Published - Mar 1 2015

Keywords

age
allograft failure
cystic fibrosis
lung transplantation
survival

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/petr.12401

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title = "High-risk age window for mortality in children with cystic fibrosis after lung transplantation",

abstract = "LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.",

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author = "Don Hayes and McCoy, {Karen S.} and Whitson, {Bryan A.} and Mansour, {Heidi M.} and Tobias, {Joseph D.}",

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doi = "10.1111/petr.12401",

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AU - Hayes, Don

AU - McCoy, Karen S.

AU - Whitson, Bryan A.

AU - Mansour, Heidi M.

AU - Tobias, Joseph D.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.

AB - LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.

KW - age

KW - allograft failure

KW - cystic fibrosis

KW - lung transplantation

KW - survival

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High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Abstract

Keywords

ASJC Scopus subject areas

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