High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy: Technical note

Arne Ekstrom, Nanthia Suthana, Eric Behnke, Noriko Salamon, Susan Bookheimer, Itzhak Fried

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Localization and targeting of depth electrodes in specific regions of the human brain is critical for accurate clinical diagnoses and treatment as well as for neuroscientific electrophysiological research. By using high-resolution magnetic resonance imaging combined with 2D computational unfolding, the authors present a method that improves electrode localization in the medial temporal lobe. This method permits visualization of electrode placements in subregions of the hippocampus and parahippocampal gyrus, allowing for greater specificity in relating electrophysiological and anatomical features in the human medial temporal lobe. Such methods may be extended to therapeutic procedures targeting specific neuronal circuitry in subfields of structures deep in the human brain.

Original languageEnglish (US)
Pages (from-to)812-815
Number of pages4
JournalJournal of neurosurgery
Volume108
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Coregistration
  • Depth electrode
  • Electrode localization
  • Epilepsy
  • Hippocampus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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