High-resolution 7t fMRI of human hippocampal subfields during associative learning

Nanthia A. Suthana, Markus Donix, David R. Wozny, Adam Bazih, Michael Jones, Robin M. Heidemann, Robert Trampel, Arne D. Ekstrom, Maria Scharf, Barbara Knowlton, Robert Turner, Susan Y. Bookheimer

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Examining the function of individual human hippocampal subfields remains challenging because of their small sizes and convoluted structures. Previous human fMRI studies at 3 T have successfully detected differences in activation between hippo-campal cornu ammonis (CA) field CA1, combined CA2, CA3, and dentate gyrus (DG) region (CA23DG), and the subiculum during associative memory tasks. In this study, we investigated hippocampal subfield activity in healthy participants using an associative memory paradigm during high-resolution fMRI scanning at 7 T. We were able to localize fMRI activity to anterior CA2 and CA3 during learning and to the posterior CA2 field, the CA1, and the posterior subiculum during retrieval of novel associations. These results provide insight into more specific human hippocampal subfield functions underlying learning and memory and a unique opportunity for future investigations of hippocampal subfield function in healthy individuals as well as those suffering from neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)1194-1206
Number of pages13
JournalJournal of cognitive neuroscience
Volume27
Issue number6
DOIs
StatePublished - Jun 5 2015
Externally publishedYes

ASJC Scopus subject areas

  • Cognitive Neuroscience

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