High performance liquid chromatography of a new anticancer drug, ADCA--physicochemical properties and pharmacokinetics

Peng Yei-Mei Peng; Thomas P. Davis; David S. Alberts

doi:10.1016/0024-3205(81)90329-5

High performance liquid chromatography of a new anticancer drug, ADCA--physicochemical properties and pharmacokinetics

Peng Yei-Mei Peng, Thomas P. Davis, David S. Alberts

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20 Scopus citations

Abstract

We have developed a simple, precise and sensitive high performance liquid chromatographic method for a new anticancer drug, ADCA, in biological samples. The assay has an average recovery of 80 ± 1.6% at physiological concentrations, a precision of <4% and a detection limit of 35 ng/ml plasma. Using this method, ADCA was found to be stable in water, saline, 5% dextrose, and plasma for at least 24 hours at 25°C.

Original language	English (US)
Pages (from-to)	361-369
Number of pages	9
Journal	Life Sciences
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(81)90329-5
State	Published - Jul 27 1981

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(81)90329-5

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title = "High performance liquid chromatography of a new anticancer drug, ADCA--physicochemical properties and pharmacokinetics",

abstract = "We have developed a simple, precise and sensitive high performance liquid chromatographic method for a new anticancer drug, ADCA, in biological samples. The assay has an average recovery of 80 ± 1.6% at physiological concentrations, a precision of <4% and a detection limit of 35 ng/ml plasma. Using this method, ADCA was found to be stable in water, saline, 5% dextrose, and plasma for at least 24 hours at 25°C.",

author = "{Yei-Mei Peng}, Peng and Davis, {Thomas P.} and Alberts, {David S.}",

note = "Funding Information: Supported by research grants CA-17094 from the National Health, U.S. Public Health Service, Department of Health, Welfare.",

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AU - Yei-Mei Peng, Peng

AU - Davis, Thomas P.

AU - Alberts, David S.

N1 - Funding Information: Supported by research grants CA-17094 from the National Health, U.S. Public Health Service, Department of Health, Welfare.

PY - 1981/7/27

Y1 - 1981/7/27

N2 - We have developed a simple, precise and sensitive high performance liquid chromatographic method for a new anticancer drug, ADCA, in biological samples. The assay has an average recovery of 80 ± 1.6% at physiological concentrations, a precision of <4% and a detection limit of 35 ng/ml plasma. Using this method, ADCA was found to be stable in water, saline, 5% dextrose, and plasma for at least 24 hours at 25°C.

AB - We have developed a simple, precise and sensitive high performance liquid chromatographic method for a new anticancer drug, ADCA, in biological samples. The assay has an average recovery of 80 ± 1.6% at physiological concentrations, a precision of <4% and a detection limit of 35 ng/ml plasma. Using this method, ADCA was found to be stable in water, saline, 5% dextrose, and plasma for at least 24 hours at 25°C.

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High performance liquid chromatography of a new anticancer drug, ADCA--physicochemical properties and pharmacokinetics

Abstract

ASJC Scopus subject areas

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