@article{964d81a2057d4d078dc6b082042331d0,
title = "High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis",
abstract = "Maternal obesity has been reported to be related to neurodevelopmental disorders in the offspring. However, the underlying mechanisms and effective interventions remain unclear. This cross-sectional study with 778 children aged 7–14 years in China indicated that maternal obesity is strongly associated with children's lower cognition and sociality. Moreover, it has been demonstrated that maternal obesity in mice disrupted the behavior and gut microbiome in offspring, both of which were restored by a high-fiber diet in either dams or offspring via alleviating synaptic impairments and microglial maturation defects. Co-housing and feces microbiota transplantation experiments revealed a causal relationship between microbiota and behavioral changes. Moreover, treatment with the microbiota-derived short-chain fatty acids also alleviated the behavioral deficits in the offspring of obese dams. Together, our study indicated that the microbiota-metabolites-brain axis may underlie maternal obesity-induced cognitive and social dysfunctions and that high dietary fiber intake could be a promising intervention.",
keywords = "SCFAs, cognitive deficits, dietary fiber, gut microbiota, maternal obesity, offspring, social behavioral deficits",
author = "Xiaoning Liu and Xiang Li and Bing Xia and Xin Jin and Qianhui Zou and Zhenhua Zeng and Weiyang Zhao and Shikai Yan and Ling Li and Shufen Yuan and Shancen Zhao and Xiaoshuang Dai and Fei Yin and Enrique Cadenas and Liu, {Rui Hai} and Beita Zhao and Min Hou and Zhigang Liu and Xuebo Liu",
note = "Funding Information: This work was financially supported by the National Key Research and Development Program of China (no. 2017YFD0400200), the National Natural Science Foundation of China (no. 81871118 and 81803231), the Innovative Talent Promotion Program-Technology Innovation Team (2019TD-006), the General Financial Grant from China Postdoctoral Science Foundation (no. 2016M602867), and the Special Financial Grant from China Postdoctoral Science Foundation (no. 2018T111104). Z.L. is also funded by the Tang Cornell-China Scholars Program from Cornell University in the U.S. and the Alexander Von Humboldt-Stiftung in Germany. We also thank Zixin He, Han Li, Junhe Zhao, and Hang Zhao (Northwest A&F University, China) for their help during animal experiments. Xiaoning Liu, X. Li, B.X. X.J. Q.Z. Z.Z. S. Yan, L.L. S. Yuan, S.Z. X.D. M.H. Z.L. and Xuebo Liu performed the experiments and analyzed the data; Xiaoning Liu, W.Z. F.Y. E.C. R.H.L. B.Z. M.H. Z.L. and Xuebo Liu wrote the manuscript; Xiaoning Liu, X. Li, X.J. Z.Z. S. Yan, M.H. Z.L. and Xuebo Liu prepared the figures; M.H. Z.L. and Xuebo Liu supervised the project. All authors read and approved the final manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = may,
day = "4",
doi = "10.1016/j.cmet.2021.02.002",
language = "English (US)",
volume = "33",
pages = "923--938.e6",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "5",
}