TY - CHAP
T1 - Herpes Simplex Virus Type-1
T2 - A Model for Genome Transactions
AU - Boehmer, Paul E.
AU - Villani, Giuseppe
N1 - Funding Information:
Work in the authors' laboratories is supported by grants GM62643 from the National Institutes of Health and BM 022 from the Florida Biomedical Research Program (to P. E. B.) and 4373 from the Association pour la Recherche sur le Cancer (to G. V.).
PY - 2003
Y1 - 2003
N2 - In many respects, HSV-1 is the prototypic herpes virus. However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage. Like eukaryotic chromosomes, the HSV-1 genome contains multiple origins of replication. Replication of the HSV-1 genome is mediated by the concerted action of several virus-encoded proteins that are thought to assemble into a multiprotein complex. Several host-encoded factors have also been implicated in viral DNA replication. Furthermore, replication of the HSV-1 genome is known to be closely associated with homologous recombination that, like in many cellular organisms, may function in recombinational repair. Finally, recent data have shed some light on the interaction of essential HSV-1 replication proteins, specifically its DNA polymerase and DNA helicases, with damaged DNA.
AB - In many respects, HSV-1 is the prototypic herpes virus. However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage. Like eukaryotic chromosomes, the HSV-1 genome contains multiple origins of replication. Replication of the HSV-1 genome is mediated by the concerted action of several virus-encoded proteins that are thought to assemble into a multiprotein complex. Several host-encoded factors have also been implicated in viral DNA replication. Furthermore, replication of the HSV-1 genome is known to be closely associated with homologous recombination that, like in many cellular organisms, may function in recombinational repair. Finally, recent data have shed some light on the interaction of essential HSV-1 replication proteins, specifically its DNA polymerase and DNA helicases, with damaged DNA.
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U2 - 10.1016/S0079-6603(03)75005-3
DO - 10.1016/S0079-6603(03)75005-3
M3 - Chapter
C2 - 14604012
AN - SCOPUS:1542780790
SN - 0125400756
SN - 9780125400756
T3 - Progress in Nucleic Acid Research and Molecular Biology
SP - 139
EP - 171
BT - Progress in Nucleic Acid Research and Molecular Biology
ER -