Hepatopulmonary syndrome

David G. Koch; Michael B. Fallon

doi:10.1016/j.cld.2014.01.003

Hepatopulmonary syndrome

David G. Koch, Michael B. Fallon

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

The hepatopulmonary syndrome (HPS) is a pulmonary complication of cirrhosis and/or portal hypertension whereby patients develop hypoxemia as a result of alterations in pulmonary microvascular tone and architecture. HPS occurs in up to 30% of patients with cirrhosis. Although the degree of hypoxemia does not reliably correlate with the severity of liver disease, patients with HPS have a higher mortality than do patients with cirrhosis without the disorder. There has been progress into defining the mechanisms that lead to hypoxemia in HPS, but to date there are no therapeutic options for HPS aside from liver transplantation.

Original language	English (US)
Pages (from-to)	407-420
Number of pages	14
Journal	Clinics in liver disease
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/j.cld.2014.01.003
State	Published - May 2014
Externally published	Yes

Keywords

Contrast echocardiography
Hepatopulmonary syndrome
Hypoxemia
Intrapulmonary vasodilatation
Liver transplantation
Portal hypertension

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2014.01.003

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title = "Hepatopulmonary syndrome",

abstract = "The hepatopulmonary syndrome (HPS) is a pulmonary complication of cirrhosis and/or portal hypertension whereby patients develop hypoxemia as a result of alterations in pulmonary microvascular tone and architecture. HPS occurs in up to 30% of patients with cirrhosis. Although the degree of hypoxemia does not reliably correlate with the severity of liver disease, patients with HPS have a higher mortality than do patients with cirrhosis without the disorder. There has been progress into defining the mechanisms that lead to hypoxemia in HPS, but to date there are no therapeutic options for HPS aside from liver transplantation.",

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AU - Fallon, Michael B.

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AB - The hepatopulmonary syndrome (HPS) is a pulmonary complication of cirrhosis and/or portal hypertension whereby patients develop hypoxemia as a result of alterations in pulmonary microvascular tone and architecture. HPS occurs in up to 30% of patients with cirrhosis. Although the degree of hypoxemia does not reliably correlate with the severity of liver disease, patients with HPS have a higher mortality than do patients with cirrhosis without the disorder. There has been progress into defining the mechanisms that lead to hypoxemia in HPS, but to date there are no therapeutic options for HPS aside from liver transplantation.

KW - Contrast echocardiography

KW - Hepatopulmonary syndrome

KW - Hypoxemia

KW - Intrapulmonary vasodilatation

KW - Liver transplantation

KW - Portal hypertension

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Hepatopulmonary syndrome

Abstract

Keywords

ASJC Scopus subject areas

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