Hepatitis B immune globulin

Shahid Habib, Obaid S. Shaikh

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Hepatitis B immune globulin (HBIG) is a purified solution of human immunoglobulin that has high titers of antibody to hepatitis B surface antigen (anti-HBs). It is derived from plasma donated by individuals immune to hepatitis B viral infection. HBIG is widely administered to confer passive prophylactic immunity against the hepatitis B virus because of the ability of anti-HBs to neutralize hepatitis B virions. However, it is not indicated for the treatment of acute or chronic hepatitis B. The use of HBIG is recommended in the following clinical situations: i) Acute exposure to blood and secretions containing hepatitis B surface antigen (HBsAg); ii) sexual contact with HBsAg-positive persons; iii) household exposure to persons with acute hepatitis B; iv) perinatal exposure of infants born to HBsAg-positive mothers; v) liver transplantation.

Original languageEnglish (US)
Pages (from-to)379-394
Number of pages16
JournalDrugs of Today
Issue number6
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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