Abstract
Chronic liver disease and ALF disrupt normal homeostasis and cause systemic manifestations that may dominate the clinical features of liver disease. The pathophysiology of cirrhosis contributes to a cascade of changes throughout the body. The primary extrahepatic manifestations discussed are hepatic encephalopathy, hepatorenal syndrome, and portopulmonary hypertension, which can cause significant morbidity and mortality prior to LT. A variety of endocrine disorders may also occur. Most of these extrahepatic syndromes are reversible with LT.
Original language | English (US) |
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Title of host publication | Sleisenger and Fordtran's Gastrointestinal and Liver Disease-2 Volume Set, 11th Edition |
Subtitle of host publication | Pathophysiology, Diagnosis, Management |
Publisher | Elsevier |
Pages | 1486-1498.e8 |
ISBN (Electronic) | 9780323609623 |
ISBN (Print) | 9780323710954 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Coagulopathy
- endocrine dysfunction
- hepatic encephalopathy
- hepatopulmonary syndrome
- hepatorenal syndrome
- portopulmonary hypertension
ASJC Scopus subject areas
- General Medicine