Hepatic clearance of Salmonella typhimurium in silica treated mice

R. L. Friedman, R. J. Moon

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Scanning electron microscopy demonstrates that crystalline silica destroys liver Kupffer cells but has no other obvious deleterious effects on the liver. Silica-treated livers still retain the ability to trap large numbers of bacteria perfused through the portal vein even though the rate of clearance is well below normal. In vivo, silica treatment decreases the rate of bacterial clearance from the blood, alters the in vivo organ distribution of cleared bacteria, and decreases the mean lethal dose of Salmonella typhimurium over 100-fold. Cumulatively, the data indicate that silica treatment enhances susceptibility to gram-negative infection, probably by destruction of macrophages.

Original languageEnglish (US)
Pages (from-to)1005-1012
Number of pages8
JournalInfection and Immunity
Issue number3
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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