Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

Fiesky A. Nunez; Michael F. Callahan; Simon Trach; Luke R. Burnett; Victor Kislukhin; Thomas L. Smith; Mark Van Dyke

doi:10.3109/21691401.2012.747533

Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

Fiesky A. Nunez, Michael F. Callahan, Simon Trach, Luke R. Burnett, Victor Kislukhin, Thomas L. Smith, Mark Van Dyke

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.

Original language	English (US)
Pages (from-to)	293-303
Number of pages	11
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	41
Issue number	5
DOIs	https://doi.org/10.3109/21691401.2012.747533
State	Published - Oct 2013
Externally published	Yes

Keywords

Hyperoncotic
Hyperviscous colloid
Hypovolemia
Keratin biomaterials
Keratose
Low volume resuscitation
Permissive hypotension
Resuscitation

ASJC Scopus subject areas

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

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10.3109/21691401.2012.747533

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@article{e421bb0842d74d4e856e74377160bcde,

title = "Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid",

abstract = "Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.",

keywords = "Hyperoncotic, Hyperviscous colloid, Hypovolemia, Keratin biomaterials, Keratose, Low volume resuscitation, Permissive hypotension, Resuscitation",

author = "Nunez, {Fiesky A.} and Callahan, {Michael F.} and Simon Trach and Burnett, {Luke R.} and Victor Kislukhin and Smith, {Thomas L.} and {Van Dyke}, Mark",

note = "Funding Information: Partial funding for this project was provided by KeraNetics LLC and NIH/NHLBI (grant no. 1R43HL099010-01A1).",

year = "2013",

month = oct,

doi = "10.3109/21691401.2012.747533",

language = "English (US)",

volume = "41",

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AU - Nunez, Fiesky A.

AU - Callahan, Michael F.

AU - Trach, Simon

AU - Burnett, Luke R.

AU - Kislukhin, Victor

AU - Smith, Thomas L.

AU - Van Dyke, Mark

N1 - Funding Information: Partial funding for this project was provided by KeraNetics LLC and NIH/NHLBI (grant no. 1R43HL099010-01A1).

PY - 2013/10

Y1 - 2013/10

N2 - Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.

AB - Death after severe hemorrhage remains an important cause of mortality in people under 50 years of age. Keratin resuscitation fluid (KRF) is a novel resuscitation solution made from keratin protein that may restore cardiovascular stability. This postulate was tested in rats that were exsanguinated to 40% of their blood volume. Test groups received either low or high volume resuscitation with either KRF or lactated Ringer's solution. KRF low volume was more effective than LR in recovering cardiac function, blood pressure and blood chemistry. Furthermore, in contrast to LR-treated rats, KRF-treated rats exhibited vital signs that resembled normal controls at 1-week.

KW - Hyperoncotic

KW - Hyperviscous colloid

KW - Hypovolemia

KW - Keratin biomaterials

KW - Keratose

KW - Low volume resuscitation

KW - Permissive hypotension

KW - Resuscitation

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JO - Artificial Cells, Nanomedicine and Biotechnology

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ER -

Hemodynamic recovery after hypovolemic shock with lactated Ringer's and keratin resuscitation fluid (KRF), a novel colloid

Abstract

Keywords

ASJC Scopus subject areas

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